A new study by researchers from the University of California, Berkeley, and Berkeley-based Aduro BioTech provides clues why killed and severely attenuated vaccines don’t always work. It also suggests ways to engineer an attenuated vaccine to make it as potent as a live vaccine but as safe as a killed vaccine.
The findings support a new hypothesis about how the innate immune system distinguishes pathogenic from non-pathogenic microbes, proposed by Professor Daniel Portnoy, UC Berkeley colleague Russell Vance, assistant professor of molecular and cell biology, and Ralph Isberg of Tufts University in the July 23 issue of the journal Cell Host & Microbe.
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